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Caveolin 1 Rabbit mAb#52197

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Product Detail

Product NameCaveolin 1 Rabbit mAb

Clone No.S01-9C9

Host SpeciesRecombinant Rabbit

ClonalityMonoclonal

IsotypeRabbit IgG

PurificationAffinity Purified

ApplicationsWB IHC

Species ReactivityHuman

Immunogen DescA synthetic peptide of human Caveolin-1

ConjugateUnconjugated

Other NamesCGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085

Accession NoSwiss-Prot:Q03135
GeneID:857

Uniprot Q03135

Gene ID 857

Calculated MWCalculated MW: 20 kDa; Observed MW: 20 kDa

Concentration0.3 mg/ml

Formulation50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

StorageStore at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.

Application Details
WB: 1/1000-1/5000; IHC: 1/20
Western blot detection of Caveolin-1 in Hela cell lysates using Caveolin-1 Rabbit mAb(1:1000 diluted).Predicted band size:20kDa.Observed band size:20kDa.
Immunohistochemistry of Caveolin-1 in paraffin-embedded Human breast cancer tissue using Caveolin-1 Rabbit mAb at dilution 1/20
Swiss-Prot Acc.Q03135.May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity . Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564).

If you have published an article using product 52197, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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