Product Detail
Product NameCIP4 Rabbit mAb
Clone No.S01-6B7
Host SpeciesRecombinant Rabbit
ClonalityMonoclonal
IsotypeRabbit IgG
PurificationAffinity Purified
ApplicationsWB
Species ReactivityHuman
Immunogen DescA synthetic peptide of human Cip4
ConjugateUnconjugated
Other NamesSTP; CIP4; HSTP; STOT; TRIP-10
Accession NoSwiss-Prot:Q15642
GeneID:9322
Uniprot
Q15642
Gene ID
9322
Calculated MWCalculated MW: 68 kDa; Observed MW: 80 kDa
Concentration0.3 mg/ml
Formulation50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
StorageStore at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
Application Details
WB: 1/1000-1/5000
Western blot detection of Cip4 in K562,C6,3T3,Hela cell lysates using Cip4 Rabbit mAb(1:1000 diluted).Predicted band size:68kDa.Observed band size:80kDa.
Swiss-Prot Acc.Q15642.Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling . Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
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