Product Detail
Product NameTranscriptional Enhancer Factor TEF 1 Rabbit mAb
Clone No.S05-1H3
Host SpeciesRecombinant Rabbit
ClonalityMonoclonal
IsotypeRabbit IgG
PurificationAffinity Purified
ApplicationsWB
Species ReactivityHuman,Mouse,Rat
Immunogen DescA synthetic peptide of human TEAD-1
ConjugateUnconjugated
Other NamesAA; REF1; TCF13; TEF-1; NTEF-1; TCF-13; TEAD-1
Accession NoSwiss-Prot:P28347
GeneID:7003
Uniprot
P28347
Gene ID
7003
Calculated MWCalculated MW: 48 kDa; Observed MW: 48 kDa
Concentration0.3 mg/ml
Formulation50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
StorageStore at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
Application Details
WB: 1/2000-1/10000;
Western blot detection of TEF1/TEAD-1 in C6,CHO-K1,Hela cell lysates using TEF1/TEAD-1 Rabbit mAb(1:1000 diluted).Predicted band size:48kDa.Observed band size:48kDa.
Swiss-Prot Acc.P28347.Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
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