Product Detail
Product NameTRIM56 Rabbit mAb
Clone No.S02-8A3
Host SpeciesRecombinant Rabbit
ClonalityMonoclonal
IsotypeRabbit IgG
PurificationAffinity Purified
ApplicationsWB IF
Species ReactivityHuman
Immunogen DescA synthetic peptide of human TRIM56
ConjugateUnconjugated
Other NamesRING finger protein 109; RNF109
Accession NoSwiss-Prot:Q9BRZ2
GeneID:81844
Uniprot
Q9BRZ2
Gene ID
81844
Calculated MWCalculated MW: 82 kDa; Observed MW: 82 kDa
Concentration0.3 mg/ml
Formulation50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
StorageStore at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
Application Details
WB: 1/2000-1/10000; ICC/IF: 1/50;
Western blot detection of TRIM56 in Hela cell lysates using TRIM56 Rabbit mAb(1:1000 diluted).Predicted band size:82kDa.Observed band size:82kDa.
Immunocytochemistry of TRIM56(green) in Hela cells using TRIM56 Rabbit mAb at dilution 1/50, and DAPI(blue)
Swiss-Prot Acc.Q9BRZ2.E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta . Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
If you have published an article using product 52633, please notify us so that we can cite your literature.