Product Detail
Product NameCD68 Rabbit Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB,IHC,IF
Species ReactivityHuman,Mouse,Rat
Immunogen DescRecombinant fusion protein of human CD68 (NP_001242.2).
ConjugateUnconjugated
Other NamesCD68;GP110;LAMP4;SCARD1
Accession NoSwiss Prot:P34810
GeneID:968
Uniprot
P34810
Calculated MW31kDa/34kDa/37kDa
Sdspage MW80-110KDa
FormulationBuffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Immunohistochemistry of paraffin-embedded Human oophoroma using CD68 at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Mouse spleen using CD68 at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using CD68 Polyclonal at 1:1000 dilution.
Western blot analysis of extracts of Rat thymus, using CD68 Polyclonal at 1:1000 dilution.
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
If you have published an article using product 53543, please notify us so that we can cite your literature.
et al,Engineering extracellular vesicles derived from endothelial cells sheared by laminar flow for anti-atherosclerotic therapy through reprogramming macrophage.
, (2025),
PMID:
39270628