Product Detail
Product NameRecombinant Human Probable global transcription activator SNF2L2(SMARCA2),partial
Host SpeciesE.coli
PurificationGreater than 90% as determined by SDS-PAGE.
Immunogen DescExpression Region:700-1216aa
Sequence Info:Partial
Other NamesATP-dependent helicase SMAR;CA2BRG1-associated factor 190B
Accession NoP51531
Uniprot
P51531
Gene ID
6595;
Calculated MW75.7 kDa
FormulationTris-based buffer50% glycerol
StorageThe shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20˚C,-80˚C. The shelf life of lyophilized form is 12 months at -20˚C,-80˚C.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.
Tag InfoN-terminal 6xHis-SUMO-tagged
Application Details
Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Belongs to the neural progenitors-specific chromatin rodeling complex (npBAF complex) and the neuron-specific chromatin rodeling complex (nBAF complex). During neural development a switch from a st,progenitor to a postmitotic chromatin rodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural st,progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A,BAF53A and PHF10,BAF45A, are exchanged for homologous alternative ACTL6B,BAF53B and DPF1,BAF45B or DPF3,BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal,proliferative capacity of the multipotent neural st cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth .
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15-25 business day
