Product Detail
Product NameRecombinant Human Suppressor of cytokine signaling 1(SOCS1)
Host SpeciesE.coli
PurificationGreater than 90% as determined by SDS-PAGE.
Immunogen DescExpression Region:1-211aa
Sequence Info:Full Length
Other NamesJAK-binding protein ;JABSTAT-induced STAT inhibitor 1 ;SSI-1Tec-interacting protein 3 ;TIP-3
Accession NoO15524
Uniprot
O15524
Gene ID
8651;
Calculated MW27.6 kDa
FormulationTris-based buffer50% glycerol
StorageThe shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20˚C,-80˚C. The shelf life of lyophilized form is 12 months at -20˚C,-80˚C.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.
Tag InfoN-terminal 6xHis-tagged
Application Details
SOCS family proteins form part of a classical negative feedback syst that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK,STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival . Probable substrate recognition component of an ECS (Elongin BC-CUL2,5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ses to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
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15-25 business day
