Product Detail
Product NameRecombinant Sheep Tumor necrosis factor(TNF)Partial
Host SpeciesE.coli
PurificationGreater than 90% as determined by SDS-PAGE.
Immunogen DescExpression Region:78-234aa
Sequence Info:Partial
Other NamesCachectin;TNF-alphaTumor necrosis factor ligand superfamily member 2 ;TNF-a
Accession NoP23383
Uniprot
P23383
Gene ID
443540;
Calculated MW44.2 kDa
FormulationTris-based buffer50% glycerol
StorageThe shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20˚C,-80˚C. The shelf life of lyophilized form is 12 months at -20˚C,-80˚C.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.
Tag InfoN-terminal GST-tagged
Application Details
Cytokine that binds to TNFRSF1A,TNFR1 and TNFRSF1B,TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
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15-25 business day
