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Mouse Anti-Human CD274 (PD-L1) mAb

CM027
Review: comment rank 5 pdf
  Catalog No. Package Size Price
CM027-1 25ug $139.00
CM027-2 100ug $378.00

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Description
  • Product Name Mouse Anti-Human CD274 (PD-L1) mAb
  • Host Species Mouse
  • Clonality Monoclonal
  • Clone No. 4C5
  • Isotype Mouse IgG1, κ
  • Applications IHC
  • Species Reactivity Hu
  • Immunogen Description PD-L1 protein
  • Alternative Names CD274
  • Storage Store protected from light at 2-8˚C. Do not freeze. The expiration date is indicated on the vial label.
Application Details

Preparation:This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with PD-L1 protein). IgG1 fraction of culture supernatant from the hybridoma was purified by protein G affinity chromatography.

Images
  • Mouse Anti-Human CD274 (PD-L1) mAb - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded normal human tonsil using PD-L1 mAb (IHC Specific)

  • Mouse Anti-Human CD274 (PD-L1) mAb - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using PD-L1 mAb (IHC Specific)

Product Description
B7-H1 (also known as PD-L1 or CD274) is a B7 family member and it is a ligand for PD-1 (programmed death-1, a member of the CD28 family). PD-L1 is constitutively expressed on a wide variety of immunocytes and nonhematopoietic cell types including some malignant tumors, suggesting the potential mechanism of immune evasion. Emerging data suggest that patients whose tumors overexpress PD-L1 by IHC have improved clinical outcomes with anti-PD-1Cdirected therapy. The use of PD-L1 (B7-H1) immunohistochemistry (IHC) as a predictive biomarker is important for anti-PD-1Cdirected therapy in human cancer.
    Please let us know if you have published research using #CM027 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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