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Tau(Phospho-Ser262) Antibody #11111

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Catalog No. Package Size Price Quantity
50ul $219.00
100ul $319.00
Availability:Yes
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Description
  • Product NameTau(Phospho-Ser262) Antibody
  • Host SpeciesRabbit
  • ClonalityPolyclonal
  • PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • ApplicationsWB IHC IF
  • Species ReactivityHu Ms Rt
  • SpecificityThe antibody detects endogenous level of Tau only when phosphorylated at serine 262.
  • Immunogen TypePeptide-KLH
  • Immunogen DescriptionPeptide sequence around phosphorylation site of serine 262 (I-G-S(p)-T-E) derived from Human Tau.
  • Target NameTau
  • ModificationPhospho
  • Alternative Names    MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
  • Uniprot P10636
  • Gene ID 4137;
  • Accession No. Swiss-Prot: P10636
    NCBI Protein: NP_001116538.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Background

Published Papers

FoxO1 overexpression reduces Aβ production and tau phosphorylation in vitro. In Neurosci Lett on 2020 Nov 1 by Wei Zhang, Shanshan Bai,et al..PMID:32860886, , (2020),
PMID: 32860886
Trillium tschonoskii maxim extract attenuates abnormal Tau phosphorylation.Neural Regen Res.In Neural Regen Res.On 2018 May by Luo HB, Shang N. et al..PMID: 29863023, , (2018),
PMID: 29863023
Tau-Induced Ca2+/Calmodulin-Dependent Protein Kinase-IV Activation Aggravates Nuclear Tau Hyperphosphorylation .In Neurosci Bull. On 2018 Apr by Wei YP, Ye JW et al..PMID: 28646348, , (2018),
PMID: 28646348
Extrasynaptic NMDA Receptor-Induced Tau Overexpression Mediates Neuronal Death Through Suppressing Survival Signaling ERK Phosphorylation.In Cell Death Dis on 2016 Nov 3 by Xu-Ying Sun , Qing-Zhang Tuo et al..PMID: 27809304, , (2016),
PMID: 27809304
View All Published Papers Zinc binds to and directly inhibits protein phosphatase 2A in vitro.In Neurosci Bull.On 2015 Jun by Xiong Y, Luo DJ et al..PMID:25854679 , , (2015),
PMID: 25854679
A novel mechanism of spine damages in stroke via DAPK1 and tau.In Cereb Cortex on 2015 Nov by Lei Pei, Shan Wang et al..PMID: 25995053 , , (2015),
PMID: 25995053
Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice. In J Nutr Biochem on 2015 Dec by Hisham Qosa, Loqman A Mohamed,et al..PMID:26344778, , (2015),
PMID: 26344778
Hyperphosphorylation and cleavage at D421 enhance tau secretion. In PLoS One on 2012 by Vanessa Plouffe, Nguyen-Vi Mohamed, et al..PMID: 22615831, , (2012),
PMID: 22615831
The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. In Neuroscience on 2010 Jun 30 by J Bertrand, V Plouffe, et al..PMID: 20394726, , (2010),
PMID: 20394726
Please let us know if you have published research using #11111 so that we can cite your reference.

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Application

WBWestern Blotting

IHCImmunohistochemistry

IFImmunofluorescence

ICCImmunocytochemistry

FCFlow Cytometry

IPImmunoprecipitation

EELISA

DBDot Blotting

ChIPChromatin Immunoprecipitation

GICAGold Immunochromatography Assay

NCNegative Control

Species Reactivity

HuHuman

MsMouse 

RtRat 

Dm Drosophila melanogaster

C Caenorhabditis elegans

MkMonkey

RbRabbit

B Bovine 

D Dog

PPig

HmHamster

ChHm Chinese Hamster 

ChkChicken  

ShpSheep