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Tau(Phospho-Ser404) Antibody #11112

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Catalog No. Package Size Price Quantity
50ul $219.00
100ul $319.00
Availability:Yes
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Description
  • Product NameTau(Phospho-Ser404) Antibody
  • Host SpeciesRabbit
  • ClonalityPolyclonal
  • PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • ApplicationsWB IHC IF
  • Species ReactivityHu Ms Rt
  • SpecificityThe antibody detects endogenous level of Tau only when phosphorylated at serine 404.
  • Immunogen TypePeptide-KLH
  • Immunogen DescriptionPeptide sequence around phosphorylation site of serine 404 (D-T-S(p)-P-R) derived from Human Tau.
  • Target NameTau
  • ModificationPhospho
  • Alternative Names    MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
  • Uniprot P10636
  • Gene ID 4137;
  • Accession No. Swiss-Prot: P10636
    NCBI Protein: NP_001116538.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Background

Published Papers

Protection of melatonin against acidosis-induced neuronal injuries.In J Cell Mol Med on 2020 May 4 by Shi Y, Cai EL, et al..PMID: 32364678, , (2020),
PMID: 32364678
Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice. In FASEB J on 2020 Dec by Ying Zhou, Dichen Yang, et al..PMID:33070372, , (2020),
PMID: 33070372
FoxO1 overexpression reduces Aβ production and tau phosphorylation in vitro. In Neurosci Lett on 2020 Nov 1 by Wei Zhang, Shanshan Bai,et al..PMID:32860886, , (2020),
PMID: 32860886
Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease. In J Neurochem on 2020 Aug by Tong-Yao Hou, Yang Zhou,et al..PMID:31951013, , (2020),
PMID: 31951013
View All Published Papers MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration. In Autophagy on 2020 Apr by Qiong Feng, Yu Luo, et al..PMID:31223056, , (2020),
PMID: 31223056
Liraglutide Ameliorates HyperhomocysteInemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular TargetIng. In Neurosci Bull on 2019 Jan 10 by Zhang Y, Xie JZ, et al..PMID: 30632006, , (2019),
PMID: 30632006
NeurotrophIn receptor p75 mediates amyloid β-Induced tau pathology. In Neurobiol Dis on 2019 Dec by Shen LL, Li WW, et al..PMID:31394202, , (2019),
PMID: 31394202
Moringa Oleifera Alleviates Homocysteine-Induced Alzheimer's Disease-Like Pathology and Cognitive Impairments.In J Alzheimers Dis.On 2018 by Mahaman YAR, Huang F et al..PMID:29710724, , (2018),
PMID: 29710724
Trillium tschonoskii maxim extract attenuates abnormal Tau phosphorylation.Neural Regen Res.In Neural Regen Res.On 2018 May by Luo HB, Shang N. et al..PMID: 29863023, , (2018),
PMID: 29863023
Evidence of altered depression and dementia-related proteins in the brains of young rats after ovariectomy. In J Neurochem. On 2018 Aug 8 by Fang YY1, Zeng P et al..PMID: 29939407 , , (2018),
PMID: 29939407
CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimers Disease.In Cell Rep. On 2018 Jul 17 by Shentu YP, Huo Y et al..PMID:30021167, , (2018),
PMID: 30021167
Methanolic extract of Tamarix Gallica attenuates hyperhomocysteinemia induced AD-like pathology and cognitive impairments in rats.In Aging (Albany NY). On 2018 Nov 12 by Salissou MTM, Mahaman YAR et al..PMID:30425189, , (2018),
PMID: 30425189
Tau-Induced Ca2+/Calmodulin-Dependent Protein Kinase-IV Activation Aggravates Nuclear Tau Hyperphosphorylation .In Neurosci Bull. On 2018 Apr by Wei YP, Ye JW et al..PMID: 28646348, , (2018),
PMID: 28646348
Adiponectin Attenuates Streptozotocin-Induced Tau Hyperphosphorylation and Cognitive Deficits by Rescuing PI3K/Akt/GSK-3β Pathway. In Neurochem Res.On 2018 Feb by Xu ZP, Gan GS et al..PMID: 29098530, , (2018),
PMID: 29098530
Sex dimorphism profile of Alzheimer's disease-type pathologies in an APP/PS1 mouse model.In Neurotox Res on 2016 Feb by Shu-Sheng Jiao, Xian-Le Bu et al..PMID:26707129, , (2016),
PMID: 26707129
Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease.In Transl Psychiatry on 2016 Oct 4 by S-S Jiao , L-L Shen et al..PMID:27701410 , , (2016),
PMID: 27701410
FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation. In PLoS One on 2013 Nov 4 by Xiu-Qi Bao, Ning Li, et al..PMID: 24223757, , (2013),
PMID: 24223757
Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling.In J Neurochem on 2012 Jan by Chen LM, Xiong YS,et al..PMID:21496024, , (2012),
PMID: 21496024
Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). In J Biol Chem on 2012 Mar 30 by Xu-Ying Sun, Yu-Ping Wei, et al..PMID: 22334661 , , (2012),
PMID: 22334661
Please let us know if you have published research using #11112 so that we can cite your reference.

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Application

WBWestern Blotting

IHCImmunohistochemistry

IFImmunofluorescence

ICCImmunocytochemistry

FCFlow Cytometry

IPImmunoprecipitation

EELISA

DBDot Blotting

ChIPChromatin Immunoprecipitation

GICAGold Immunochromatography Assay

NCNegative Control

Species Reactivity

HuHuman

MsMouse 

RtRat 

Dm Drosophila melanogaster

C Caenorhabditis elegans

MkMonkey

RbRabbit

B Bovine 

D Dog

PPig

HmHamster

ChHm Chinese Hamster 

ChkChicken  

ShpSheep