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GPNMB Antibody

48438
Review: comment rank 5 pdf
  Catalog No. Package Size Price
48438-1 50ul $260.00
48438-2 100ul $390.00

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Description
  • Product Name GPNMB Antibody
  • Host Species Mouse
  • Clonality Monoclonal
  • Clone No. E5-C10
  • Purification ProA affinity purified
  • Applications WB, IHC
  • Species Reactivity Hu
  • Immunogen Description Recombinant protein
  • Alternative Names Glycoprotein (transmembrane) nmb antibody
    Glycoprotein nmb antibody
    Glycoprotein nmb like protein antibody
    Gpnmb antibody
    GPNMB_HUMAN antibody
    HGFIN antibody
    NMB antibody
    Osteoactivin antibody
    Transmembrane glycoprotein antibody
    Transmembrane glycoprotein HGFIN antibody
    Transmembrane glycoprotein NMB antibody
  • Accession No. Swiss-Prot#:Q14956
  • Calculated MW 64 kDa
  • Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage Store at -20˚C
Application Details

WB: 1:500
IHC: 1:100-1:200


Images
  • GPNMB Antibody - SAB | Signalway Antibody

    Western blot analysis of GPNMB on human GPNMB recombinant protein using anti-GPNMB antibody at 1/1,000 dilution.

  • GPNMB Antibody - SAB | Signalway Antibody

    Western blot analysis of GPNMB on HEK293 (1) and GPNMB-hIgGFc transfected HEK293 (2) cell lysate using anti-GPNMB antibody at 1/1,000 dilution.

  • GPNMB Antibody - SAB | Signalway Antibody

    Western blot analysis of GPNMB on PANC-1 and PC-3 cell lysate using anti-GPNMB antibody at 1/1,000 dilution.

  • GPNMB Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-GPNMB antibody. Counter stained with hematoxylin.

  • GPNMB Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human esophagus cancer tissue using anti-GPNMB antibody. Counter stained with hematoxylin.

Background
Transmembrane glycoprotein NMB (GPNMB), also designated hematopoietic growth factor inducible neurokinin-1 (HGFIN), is a single-pass type I membrane protein. Belonging to the Pmel-17/NMB family of proteins, GPNMB acts as a melanogenic enzyme. GPNMB expression is not restricted to cells of melanocytic lineage and is highest in poorly metastatic melanoma cell lines. There is no expression of GPNMB in highly metastatic melanoma cell lines. GPNMB may play a important role in lymphohematopoietic stem cell maturation.
Regerences
1. Tsui KH et al. Glycoprotein transmembrane nmb: an androgen-downregulated gene attenuates cell invasion and tumorigenesis in prostate carcinoma cells. Prostate 72(13):1431-42 (2012).
2. Williams MD et al. GPNMB expression in uveal melanoma: a potential for targeted therapy. Melanoma Res 20(3):184-90 (2010).
    Please let us know if you have published research using #48438 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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