Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
[1] "Two distinct forms of active transcription factor CREB (cAMP response element binding protein)."Berkowitz L.A., Gilman M.Z.Proc. Natl. Acad. Sci. U.S.A. 87:5258-5262(1990) [2] "Multiple cDNA clones encoding nuclear proteins that bind to the tax-dep
