• Product NameKLRA1 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAffinity chromatography purified via peptide column
• ApplicationsELISA WB ICC
• Species ReactivityHu Ms Rt
• SpecificityAt least three isoforms of KLRA1 are known to exist; this antibody recognizes only the long isoform.
• Immunogen TypePeptide
• Immunogen DescriptionRaised against a 13 amino acid peptide near the center of human KLRA1.
• Target NameKLRA1
• Alternative Names    Killer cell lectin-like receptor subfamily A member 1, Ly49, Ly49L
• Accession No. Swiss-Prot:EAW96194
  Gene ID:
• Concentration 1mg/ml
• Formulation Supplied in PBS containing 0.02% sodium azide.
• Storage Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

KLRA1 (also known as Ly49L) is a member of the LY49 family of receptors in Natural Killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA1 is thought to be an activating receptor, inducing DAP12 phosphorylation in response to antibody-mediated cross-linking of KLRA1 on NK cells.

• Western blot analysis of KLRA1 in mouse spleen tissue lysate with KLRA1 antibody at (A) 1 ug/mL and (B) 2 ug/mL.
• Immunocytochemistry of KLRA1 in 293 cells with KLRA1 antibody at 4 ug/mL.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting