• Product NameRUSC2 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAffinity chromatography purified via peptide column
• ApplicationsELISA IHC
• Species ReactivityHu
• SpecificityAt least three isoforms are known to exist; this antibody will only detect the longest isoform. This antibody is predicted to not cross-react with RUSC1.
• Immunogen TypePeptide
• Immunogen DescriptionRaised against a 15 amino acid peptide from near the carboxy terminus of human RUSC2.
• Target NameRUSC2
• Alternative Names    RUN and SH3 domain containing protein 2, Iporin
• Accession No. Swiss-Prot:Q8N2Y8
  Gene ID:9853
• UniprotQ8N2Y8
• Gene ID9853;
• Concentration 1mg/ml
• Formulation Supplied in PBS containing 0.02% sodium azide.
• Storage Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

RUSC2, also known as Iporin, shares with the related protein RUSC1 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC2 is a rab1-interacting protein that also interacts with GM130, another rab1-interacting protein. RUSC2 interacts with specific rab1 isoforms with different rab-binding specificity. It has been suggested that RUSC2 may function as a link between the targeting of ER derived vesicles triggered by the rab1 GTPase and a signaling pathway composed of proteins containing SH3 and/or poly-proline regions.

• Immunohistochemistry of RUSC2 in human placenta tissue with RUSC2 antibody at 5 ug/mL.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting