• Product NameECRG2 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAffinity chromatography purified via peptide column
• ApplicationsELISA WB
• Species ReactivityHu Ms Rt
• SpecificityECRG2 antibody is predicted to not cross-react with other ECRG family members
• Immunogen TypePeptide
• Immunogen DescriptionRaised against a 16 amino acid peptide near the carboxy terminus of human ECRG2.
• Target NameECRG2
• Alternative Names    Esophageal cancer-susceptibility gene 2 protein, ECG2, serine protease inhibitor Kazal-type 7; SPINK7
• Accession No. Swiss-Prot:P58062
  Gene ID:84651
• UniprotP58062
• Gene ID84651;
• Concentration 1mg/ml
• Formulation Supplied in PBS containing 0.02% sodium azide.
• Storage Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.

• Western blot analysis of ECRG2 in human lung tissue lysate with ECRG2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting