• Product NameCytochrome P450 2A6 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsWB
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total Cytochrome P450 2A6 protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from N-terminal of human Cytochrome P450 2A6.
• Target NameCytochrome P450 2A6
• Alternative Names    Cytochrome P450 2A6; EC 1.14.14.1; CYPIIA6; Coumarin 7-hydroxylase; P450 IIA3
• Accession No. Swiss-Prot: P11509
  NCBI Gene ID: 1548
• UniprotP11509
• Gene ID1548;
• SDS-PAGE MW 56kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• Western blotting: 1:500~1:3000
  
  

Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.

Miles J.S., ic Acids Res. 17:2907-2917(1989).
Yamano S., Biochemistry 29:1322-1329(1990).
Saito S., J. Hum. Genet. 48:249-270(2003).

• Western blot analysis of extracts from Jurkat cells, using Cytochrome P450 2A6 antibody #34232.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting