• Product NameFRS3 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsWB
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total FRS3 protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from internal of human FRS3.
• Target NameFRS3
• Alternative Names    fibroblast growth factor receptor substrate 3; FRS2B; FRS2beta; MGC17167; SNT-2
• Accession No. Swiss-Prot: O43559
  NCBI Gene ID: 10817
• UniprotO43559
• Gene ID10817;
• SDS-PAGE MW 54kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• Western blotting: 1:500~1:3000
  
  

Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

Xu H., J. Biol. Chem. 273:17987-17990(1998).
Mungall A.J., Nature 425:805-811(2003).
The MGC Project Team; Genome Res. 14:2121-2127(2004).

• Western blot analysis of extracts from COS-7 cells, using FRS3 antibody #34249.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting