• Product NameSCN4A Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsWB
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total SCN4A protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from internal of human SCN4A.
• Target NameSCN4A
• Alternative Names    Sodium channel protein type 4 subunit alpha; Sodium channel protein type IV subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.4; Sodium channel protein skeletal muscle subunit alpha; SkM1
• Accession No. Swiss-Prot: P35499
  NCBI Gene ID: 6329
• UniprotP35499
• Gene ID6329;
• SDS-PAGE MW 208kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• Western blotting: 1:500~1:3000
  
  

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.

George A.L. Jr., Ann. Neurol. 31:131-137(1992).
Wang J., Biochem. Biophys. Res. Commun. 182:794-801(1992).
Tsujino A., Proc. Natl. Acad. Sci. U.S.A. 100:7377-7382(2003).

• Western blot analysis of extracts from K562 cells, using SCN4A antibody #35054.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting