• Product NameSCN2B Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsWB
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total SCN2B protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from internal of human SCN2B.
• Target NameSCN2B
• Alternative Names    Sodium channel subunit beta-2; SCN2B;
• Accession No. Swiss-Prot: O60939
  NCBI Gene ID: 6327
• UniprotO60939
• Gene ID6327;
• SDS-PAGE MW 24kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• Western blotting: 1:500~1:3000
  
  

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier By similarity.

Eubanks J., NeuroReport 8:2775-2779(1997).
Bolino A., Eur. J. Hum. Genet. 6:629-634(1998).
Cruz J.S., Science 284:711-711(1999).

• Western blot analysis of extracts from 293 cells, using SCN2B antibody #35057.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting